Background Information – We can safely and noninvasively measure GABA and functional connectivity in humans using imaging tools such as functional magnetic resonance imaging (fMRI), magnetic resonance spectroscopy (MRS), magnetoencephalography (MEG). We can modulate GABA and functional connectivity in humans using noninvasive neuromodulation tools such as repetitive transcranial magnetic stimulation (rTMS).
Study Aims – The current study seeks to first establish the relationship between local GABA concentration, structural and functional network connectivity and MEG measures of auditory and language processing in young adult volunteers without ASD and adolescents with ASD (Aim #1). We will then apply a single session of rTMS over a language processing brain region as a probe to assess the degree to which this protocol modulates GABA concentration, functional connectivity, and MEG (Aim #2). If successful, this study may inform future therapeutic trials aiming to treat the symptoms of ASD by modulating GABA concentration.
To get started:
- Navigate through the menu to learn more about the study.
- The study team will provide you with your username and password, when instructed to do so, Log in to the Study Portal to fill out questionnaires for the study
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