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About the Study

Who runs this study?

This study is being conducted by the Noninvasive Neuromodulation Unit (NNU), which is a research group within the Experimental Therapeutics and Pathophysiology Branch (ETPB) in the National Institute of Mental Health (NIMH). The NNU focuses on developing TMS protocols for the study and treatment of neuropsychiatric and neurodevelopmental disorders.

The Principal Investigator for this study is:

Sarah H. Lisanby, MD
Phone: 301-435-8031
E-mail: sarah.lisanby@nih.gov

The Lead Associate Investigator and Referral Contact for this study is:

Lindsay M. Oberman, PhD
Phone: 301-435-7962
Email: lindsay.oberman@nih.gov

The Study Coordinators are:

Jaime, Miguel
Phone: 301-496-0370
Email: miguel.jaime@nih.gov

Ekpo, Ekaete
Phone: 301-827-0963
Email: ekaete.ekpo@nih.gov

What is this study about?

The current study seeks to first establish the relationship between local GABA concentration, structural and functional network connectivity and MEG measures of auditory and language processing in young adult volunteers without ASD and adolescents with ASD (Aim #1). We will then apply a single session of rTMS over a language processing brain region as a probe to assess the degree to which this protocol modulates GABA concentration, functional connectivity, and MEG (Aim #2). If successful, this study may inform future therapeutic trials aiming to treat the symptoms of ASD by modulating GABA concentration.

What kind of commitment is involved?

For individuals without ASD, this study will involve 3 sessions (that can be completed in up to 5 visits) across 4-6 weeks. For participants with ASD, this study will involve 5 sessions (that can be completed in up to 8 visits) across 8-10 weeks. Each visit will take about 2-3 hours. There will be approximately 1 visit per week. All visits must be completed within six months of signing the consent form.

How can I ask questions or ask for help?

Email us at decibels-study@nih.gov (or click on Contact). We will respond within two business days.